What Tesamorelin is
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). It carries the complete 44-residue GHRH sequence, ending in a C-terminal amide, with one change: a trans-3-hexenoyl group is attached to the N-terminal tyrosine. That six-carbon acyl cap protects the N-terminus from dipeptidyl peptidase-4, the enzyme that otherwise removes the first two residues of GHRH. Tesamorelin is designed as an agonist of the GHRH receptor (GHRHR), a class B G protein-coupled receptor.
Tesamorelin Labs supplies it as a lyophilized powder in 10 mg vials. Each lot is tested by ILS Laboratories for HPLC purity, identity against a reference standard and net content, with a fentanyl screen, and the certificate is published here before the material is sold through Klow.bio.
Structure
At 44 residues and over 5,100 g/mol, tesamorelin is one of the larger linear peptides in research catalogues. It contains a single methionine (Met27), the residue most likely to oxidize, and no cysteine, so there are no disulfide bonds. The N-terminal trans-3-hexenoyl group and the C-terminal amide are its only modifications.
complete Tesamorelin specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.